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PROF. GEORGIA STEPHANOU
Professor in Genetics, Division of Genetics, Cell and Developmental Biology, Department of Biology,University of Patras,Patras, GREECE
E mail: geosteph@biology.upatras.gr

About Prof. Stephanou:
Prof. Georgia Stephanou, an outstanding scholar and academician and a renowned expert in the field of Genetics is presently working as Professor in Genetics in the Department of Biology at the University of Patras and Director of the Postgraduate Studies of the same Department.

Prof. Georgia Stephanou has completed her undergraduate studies in the National and Kapodistrian University of Athens. She started her research in the Laboratory of Genetics at the University of Patras and completed her PhD in Biology. She continued to work in the field of Genetics at the same Department. She teaches courses of Genetics, Medical-Human Genetics and Behavioral Genetics, in graduate and postgraduate level, at the Departments of Biology, Pharmacology, Medicine and Primary Education. Her research may be subdivided into two major topics. I) Biochemical Genetics, studying the role of heat shock proteins in acquiring thermotolerance mainly in Drosophila melanogaster. II) Genetic Toxicology-Human Genetics, using classic and molecular cytogenetic assays and giving emphasis on the effects of pharmaceutical compounds on the genetic material of various organisms, especially humans. In addition, the influence of the individual genotype, mainly of phase I and II metabolizing enzymes, on the cell response to xenobiotics, is taking into consideration. In the same field the relationship of karyotypic changes in relation to various pathologies is also investigating. Prof. Georgia Stephanou has more than 60 publications and has presented original data in more than twenty international and local conferences, while has participated in several European and Greek funded research projects. She has collaborated with various European laboratories and is member of two scientific societies and referee in two international scientific journals (British Journal of Pharmacology and Medical Science Monitor). She has supervised PhDs, MScs and postdoctoral projects. She is married to Nikos Demopoulos, Professor in Genetic Toxicology at the same Department. They have one daughter, Hara, who has just finished her PhD in Chemistry.

I. RESEARCH GROUP

Professor Georgia Stephanou developed her scientific activities within the research group of Genetic Toxicology and Environmental Mutagenesis of the Department of Biology at the University of Patras, in collaboration with Professor Nikos Demopoulos, and their postgraduate students and postdoctoral fellows. The main research target of their group is the study of the genetic alterations induced by various chemical-pharmaceutical compounds in several organisms, giving emphasis in humans, and the mechanisms by which these alterations are generated. To answer this question they use classic and molecular methodology. Since 1983, when they started to collaborate, they have published numerous papers in peer-review International journals and presented their scientific results in International and Hellenic meetings. Numerous other researchers refer their work. The Genetic Toxicology and Environmental Mutagenesis group has collaborated with various European laboratories in common EU research projects. From the activities of this group several PhD and MSc degrees have been arisen.

II. PUBLICATIONS

  1. S.N. Alahiotis and G. Stephanou (1982)
    Temperature adaptation of Drosophila populations. The heat shock protein system. Comparative Biochemistry and Physiology, 73B, p.p. 529-533.
  2. G.Stephanou and Th.Georgiadis (1982)
    IOPB Chromosome Number Reports LXXVII. Chromosome numbers of 9 species of the genus Anthemis. Taxon, Vol. 31, p. 764.
  3. Stephanou, G., Alahiotis, S., Marmaras, V. and Christodoulou, C. 1982)
    The heat shock system (HS) in Ceratitis capitata. Abstracts of Special FEBS meeting on Cell function and differentiation, p. 263, Athens.
  4. G. Stephanou and S.N. Alahiotis (1983)
    Adaptive significance of the Adh locus through the heat shock protein system in D.melanogaster. Abstracts of the International Conference in Biochemical and Developmental Genetics, p. 35, Kos, Greece.
  5. G.Stephanou and S.N. Alahiotis (1983)
    Non-Mendelian Inheritance of "heat-Sensitivity" in Drosophila melanogaster. Genetics, Vol. 103, p.p. 93-107.
  6. G. Stephanou, S.N. Alahiotis, C. Christodoulou and V.J. Marmaras (1983)
    Adaptation of Drosophila to temperature: Heat shock proteins and survival in Drosophila melanogaster. Developmental Genetics, Vol. 3, p.p. 299-308.
  7. G. Stephanou, S.N. Alahiotis, V.J. Marmaras and C. Christodoulou (1983)
    Heat shock response in Ceratitis capitata. Comparative Biochemistry and Physiology, Vol. 74B, p.p. 425-432.
  8. Stephanou, G. (1985).
    Preliminary data on the control of heat shock protein synthesis in two strains of Drosophila melanogaster and Ceratitis capitata. Genetics, Vol. 110, p. s100.
  9. G. Stephanou and S.N. Alahiotis (1986)
    Adaptive significance of the action of the Drosophila melanogaster alcohol dehydrogenase locus through the heat shock protein system. Genetica, Vol. 69, p.p. 59-68.
  10. Georgia Stephanou and Nikos A. Demopoulos (1986)
    Heat shock phenomena in Aspergillus nidulans. I. The effect of heat on mycelial protein synthesis. Current Genetics, Vol. 10, p.p. 791-796.
  11. Georgia Stephanou (1987)
    On the control of heat shock protein synthesis in Drosophila melanogaster and Ceratitis capitata. Insect Biochemistry, Vol.17, p.p. 4597-602. Insect Biochemistry and Molecular Biology.
  12. Georgia Stephanou and Nikos A. Demopoulos (1987)
    Heat shock phenomena in Aspergillus nidulans. II. Combined effect of heat and Bleomycin to heat shock protein synthesis, survival rate and induction of mutations. Current Genetics, Vol. 12, p.p. 443-448.
  13. Stephanou, G and N. Demopoulos (1988)
    Combined effect of heat and bleomycin on Aspergillus nidulans. Mutation Research, Vol. 203, p. 229.
  14. K. Psaraki, N.A. Demopoulos, G. Stephanou and C. Camoutsis (1990)
    The effect of different homo-aza-steroidal esters of m-N,N-bis-(2-chloro-ethyl) amino cinnamic acid on SCEs, chromosomal aberration frequencies and protein synthesis rate in human lymphocyte cultures. Mutation Research, Vol. 234, p. 399. Selected abstracts of the 19th Annual Meeting of EEMS, Rhodos, Greece
  15. G. Stephanou, N.A. Demopoulos and P. Catsoulacos (1990)
    The effects of a new cytostatic compound NSC 294859 on mutation rate and protein synthesis rate in different test systems. Mutation Research, Vol. 234, p. 403. Selected abstracts of the 19th Annual Meeting of EEMS, Rhodos, Greece
  16. Demopoulos, Ν.Α., Stephanou, G., Psaraki, Κ. (1990)
    Induction of Sister Chromatid Exchanges in lymphocytes from cancer patients of normal donors exposed in antitumour drugs in vivo or in vitro. In: Biomonitoring of Human Populations Exposed to Genotoxic Environmental Chemicals. CEC Contact Group Meeting Report, p.p. IV.1-IV.14. Espoο, Finland.
  17. G.Stephanou, N.A. Demopoulos and P. Catsoulacos (1991)
    Altered protein synthesis rate in ovaries of D.melanogaster caused by new antitumour agents. International Journal of Biochemistry, Vol.23, p.p.1251-1254. The International Journal of Biochemistry and Cell Biology.
  18. Stephanou G., N.A. Demopoulos and P. Catsoulacos (1991)
    Genotoxic effect of the new antitumour agent NSC 294859 tested in the Drosophila wing somatic mutation and recombination test. Mutagenesis, Vol.6, p.p.325-328.
  19. Sorsa, M., K. Autio, A. Abbodandolo, E. Carbonell, N. Demopoulos, C. Garner, M. Kirsch-Volders, R. Marcos, E. Marafante, A.T. Natarajan, E.M. Parry, K. Psaraki, G. Stephanou, A.D. Tates and R. Waters (1992)
    Evaluation of in vitro cytogenetic techniques in nine European laboratories in relation to chromosomal endpoints induced by three model mutagens. Mutation Research. Genetic Toxicology and Environmental Mutagenesis, Vol. 271, p.p. 261-267.
  20. Vlastos, D., K. Psaraki, G. Stephanou, N.A. Demopoulos and D. Tsambaos (1993) Genotoxic effects of Cetirizine dihydrochloride on human lymphocyte cultures in vitro. Mutation Research, Vol. 291, p. 283.
  21. Vlachodimitropoulos, D., H. Jarventaus, G. Stephanou, M. Sorsa, and N.A. Demopoulos (1993)
    Biomonitoring of workers occupationally exposed to 1,3 butadiene. Abstracts of 23rd annual meeting of EEMS, Barcelona, Spain.
  22. Stephanou, G, D. Vlastos, D. Vlachodimitropoulos and N.A. Demopoulos (1994)
    The effect of MNU on human lymphocyte cultures in vitro, evaluated by O6-medGuo formation and micronuclei. Abstracts of 24th annual meeting of EEMS, p.66, Poznan, Poland.
  23. M. Sorsa, K. Autio, N.A. Demopoulos, H. Järventaus, P. Rössner, R.J. Šrám, G. Stephanou and D. Vlachodimitropoulos (1994)
    Human cytogenetic biomonitoring of occupational exposure to 1,3 butadiene. Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 309, p.p. 321-326.
  24. Stephanou, G, D. Vlastos, D. Vlachodimitropoulos and N.A. Demopoulos (1994)
    The effect of MNU on human lymphocyte cultures in vitro, evaluated by O6-medGuo formation and micronuclei. Abstracts of 24th annual meeting of EEMS, p.66, Poznan, Poland.
  25. E. Carbonell, N.A Demopoulos, G. Stephanou, K. Psaraki, E.M Parry and R. Marcos (1996)
    Cytogenetic analysis in peripheral lymphocytes of cancer patients treated with cytostatic drugs : results from an EC Collaborative Study. Anti-Cancer Drugs, Vol.7, p.p. 514-519.
  26. G. Stephanou, D. Vlastos, D. Vlachodimitropoulos and N.A. Demopoulos (1996)
    A comparative study on the effect of MNU on human lymphocyte cultures in vitro evaluated by O6-mdG formation, micronuclei and sister chromatid exchanges induction. Cancer letters, Vol.109, p.p. 109-114.
  27. A.D. Tates, F.J. van Dam, F.A.de Zwart, F. Darroudi, A.T. Natarajan, P.Rössner, K. Peterková, K. Peltonen, N.A. Demopoulos, G. Stephanou, D. Vlachodimitropoulos, and R.J. Šrám (1996)
    Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene. Toxicology, Vol. 113, p.p. 91-99.
  28. V. Macheraki, V. Orphanos, S. Kamakari, M. Kokkinaki, G. Stephanou, N. Demopoulos, G. M. Maniatis, N. Moschonas and D. Spathas (1996)
    In: Use of fluorescence in situ hybridization for mapping and ordering YAC clones from chromosomal regions with suspected tumor-suppressor activity. Analytical Use of Fluorescent Probes in Oncology, pp. 419-421, Plenum Press, N.Y.
  29. K. Psaraki, N.A Demopoulos, G. Stephanou and Ch. Camoutsis (1997)
    m-N,N-bis(2-chloroethyl)aminocinnamic acid and four new homo-aza-steroidal esters induce chromosomal abnormalities and affect protein synthesis in human lymphocytes in vitro. Anti-Cancer Drugs, Vol. 8, p.p. 73-79.
  30. G. Stephanou, C. Andrianopoulos, D. Vlastos, N.A. Demopoulos and A. Russo (1997)
    Induction of micronuclei and sister chromatid exchanges in mouse splenocytes after exposure to the butadiene metabolite 3,4-epoxy-1-butene. Mutagenesis, Vol.12, p.p. 425-429.
  31. G. Stephanou, A. Russo, D. Vlastos, C. Andrianopoulos and N.A. Demopoulos (1998)
    Micronucleus induction in somatic cells of mice as evaluated after 1,3-butadiene inhalation. Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 397, p.p. 11-20.
  32. D. Vlastos, G. Stephanou and N.A. Demopoulos (1998) Effects of Cetirizine dihydrochloride on human lymphocytes in vitro. Evaluation of chromosome aberrations and sister chromatid exchanges. Skin Pharmacology and Applied Skin Physiology, Vol. 11, p.p. 104-110
  33. D. Vlastos and G. Stephanou (1998)
    Effects of Cetirizine dihydrochloride on human lymphocytes in vitro. Evaluation of clastogenic and aneugenic potential using CREST and FISH assays. Archives of Dermatological Research, 290, p.p. 312-318.
  34. R. J. Šräm, P. Rössner, K. Peltonen, K. Podrazilová, G. Mračková, N. A. Demopoulos, G. Stephanou, D. Vlachodimitropoulos, F. Darroudi, A. D. Tates (1998)
    Chromosomal aberrations, sister chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1,3-butadiene exposed workers. Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 419, p.p. 145-154.
  35. Andrianopoulos C., Stephanou G., Demopoulos Ν. A. (1999)
    Hydrochlorothiazide (HTCZ) aneugenic activity as revealed in human lymphocyte cultures treated in vitro. Proceedings of the 21st Annual Conference of the Hellenic Society for Biological Sciences, Syros, Hellas, p. 14.
  36. Vlastos D, Stephanou G (1999)
    Cetirizine effects on human lymphocytes-Reply Archives of Dermatological Research, 291, p. 245.
  37. Vlastos D, Stephanou G, Demopoulos NA (1999)
    Cetirizine effects on human lymphocytes-Reply Skin Pharmacology and Applied Skin Physiology, 12, p. 364.
  38. G. Stephanou, C. Andrianopoulos, N. A. Demopoulos and D. Tsambaos (2000) Antimutagenic effects of Acitretin. Skin Pharmacology and Applied Skin Physiology, Vol. 13, p. 209. Plenary Lecture
  39. C. Andrianopoulos, G. Stephanou, E. Politi and N. A. Demopoulos (2000). Evaluation and characterization of micronuclei induced by the antitumour agent ASE, namely 3β-hydroxy-13α-amino-13, 17-seco-5α-androstan-17-oic-13, 17-lactam-p-bis(2-chloroethyl)aminophenyl acetate in human lymphocyte cultures. Mutagenesis, Vol. 15, p.p. 215-221.
  40. P. Papapavlou, D. Vlastos, Stephanou, G and N.A. Demopoulos (2000)
    Proceedings of the 1st European Conference on pesticides and related organic micropollutants in the environment, p. 289, Ioannina, Greece.
  41. M. Tyrakis, M. Konti, C. Andrianopoulos, G. Stephanou, N.A. Demopoulos and D. Tsambaos (2001) Cytogenetic effects of the effect of the synthetic retinoid acitretin on human lymphocytes, in vitro. Proceedings of the 23rd Annual Conference of the Hellenic Society for Biological Sciences, Chios, Hellas, p. 181.
  42. S.A. Κyrtopoulos, P. Georgiadis, H. Autrup, N. A. Demopoulos, P. Farmer, Α. Haugen, K. Katsouyianni, B. Lambert, S. Overbö, R. Šräm, G. Stephanou and J. Topinka (2001) Biomarkers of genotoxicity of urban air pollution: Overview and descriptive data from a molecular epidemiology study on population exposed to moderate to low levels of polycyclic aromatic hydrocarbons (the AULIS project). Mutation Research. Genetic Toxicology and Environmental Mutagenesis, Vol. 496, p.p. 207-228.
  43. P. Papapavlou, D. Vlastos, G. Stephanou and N. A. Demopoulos (2001)
    Linuron cytogenetic activity on human lymphocytes treated in vitro. Evaluation of clastogenic and aneugenic potential using cytokinesis block micronucleus assay in combination with Fluorescence In Situ Hybridization (FISH). Fresenius Environmental Bulletin, Vol.10, p.p. 431-437.
  44. Georgia Stephanou (2002)
    Retinoid effects on spontaneous genetic alterations and on those induced by chemical and physical agents. Review article In: D. Tsambaos and H. Merk (Eds.), "Modern Trends in Skin Pharmacology: Molecular and Clinical Aspects." pp.169-188, Parissianos, Athens.
  45. K. Bakou, G. Stephanou, C. Andrianopoulos and N. A. Demopoulos (2002) Spontaneous and spindle poison-induced micronuclei and chromosome non-disjunction in cytokinesis-blocked lymphocytes from two age groups of women. Mutagenesis, Vol. 17, p.p. 233-239.
  46. Andrianopoulos C., Stephanou G., Demopoulos Ν. (2003)
    Immunofluorescence Staining Of - αnd γ- Tubulin Revealed Abnormalities In The Mitotic Spindle Of The Murine Cell Line C2c12 After Treatment With Hydrochlorothiazide (HCTZ) Proceedings of the 23rd Annual Conference of the Hellenic Society for Biological Sciences, Mytilini, Hellas, p. 29.
  47. Kouloumenta A, Stephanou G, Demopoulos N, Nikolaropoulos S. (2003)
    Fluorescence In Situ Hybridization (Fish) As A Tool To Study Structure-Genetic Activity Relationship Of Omo-Aza-Steroidal Deriva-Tives With Antineoplasmatic Activity Proceedings of the 23rd Annual Conference of the Hellenic Society for Biological Sciences, Mytilini, Hellas, p.159.
  48. Pappa A., Papadelis E., Stephanou G., Demopoulos N. (2003)
    Comparative Study Of Spontaneous MicronuCleous Frequencies In Human Peripheral Lymphocytes And Buccal Cells. Proceedings of the 23rd Annual Conference of the Hellenic Society for Biological Sciences, Mytilini, Hellas, p. 253
  49. P. Georgiadis , N. A. Demopoulos , J. Topinka , G. Stephanou , M. Stoikidou , M. Bekyrou , K. Katsouyianni , R. Šräm , H. Autrup and S. A. Kyrtopoulos (2004)
    Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke. Toxicology Letters, Vol. 149, p.p. 269-280.
  50. G. Stephanou, C. Andrianopoulos, M. Tyrakis, M. Konti, N.A. Demopoulos and D. Tsambaos (2004)
    Ιn vitro antigenotoxic potential of acitretin in human lymphocytes treated with the antineoplastic alkylating agent ASE (NSC-71964) Toxicology In Vitro, Vol. 18, p.p. 609-616.
  51. Αndrianopoulos C., Salamastrakis S., Stephanou G. Demopoulos N.A. (2005)
    Combined immunofluorescence assay of microtubules and kinetochore in C2C12 mouse cells reveals anuegenic activity of the pharmaceutical compound hydrochlorothiazide (HCTZ). Proceedings of the 1st Bioscience Conference of the University of Patras, Patras, Hellas, p. 288.
  52. Ouranou D., Stephanou G., Demopoulos N.A. (2005)
    Polymorphisms of the GSTM1 and GSTT1 genes in a sample of young individuals. Proceedings of the 1st Bioscience Conference of the University of Patras, Patras, Hellas, p. 290.
  53. Efthimiou M., Andrianopoulos C., Stephanou G., Demopoulos N.A., Nikolaropoulos S. (2005)
    The combined use of CBMN and FISH methods as a tool for cytogenetic analysis of the effect of alkylating cytostatic compounds in human lymphocytes treated in vitro. Proceedings of the 6th Conference of Medicinal Chemistry: Drug Discovery and Design. Patras, Hellas, p. 64
  54. Asimina Kouloumenta, Georgia Stephanou, Nikos A. Demopoulos, and Sotiris S. Nikolaropoulos (2005)
    Genetic effects caused by potent antileukemic steroidal esters of chlorambucil's active metabolite. Anti-Cancer Drugs, Vol. 16, p.p. 67-75.
  55. C. Andrianopoulos, G. Stephanou, N.A. Demopoulos (2005)
    Hydrochlorothiazide enhances micronucleus formation and affects chromosome segregation in cultured human lymphocytes. Abstracts of 35th Annual Meeting of the EEMS, p. 104, Kos, Greece.
  56. Efthimiou M., Andrianopoulos C., Stephanou G., Demopoulos N.A. and Nikolaropoulos S. S. (2005)
    Effects of nitrogen mustard analogues on mitotic spindle of C2C12 mouse cell line. Abstracts of 35th Annual Meeting of the EEMS, p. 109, Kos, Greece.
  57. Salamastrakis S., C. Andrianopoulos, G. Stephanou, N.A. Demopoulos (2005)
    Treatment of C2C12 mouse cell line with hydrochlorothiazide revealed microtubule disorganization and abnormal mitotic figures. Abstracts of 35th Annual Meeting of the EEMS, p. 115, Kos, Greece.
  58. Alexandra Monastirli, Georgia Stephanou, Sophia Georgiou, Constantinos Andrianopoulos, Efi Pasmatzi, Elizabeth Chroni, Aggeliki Katrivanou, Panagiotis Dimopoulos, Nikos A. Demopoulos, Dionysios Tsambaos (2005)
    Short Stature, Type E Brachydactyly, Exostoses, Gynecomastia And Cryptorchidism In A Patient With 47,Xyy/46,Xy/45,X Mosaicism The American Journal Of The Medical Sciences, Vol. 329, p.p. 208-210.
  59. Panagiotis Georgiadis, Jan Topinka, Dimitris Vlachodimitropoulos, Melpomeni Stoikidou, Maria Gioka, Georgia Stephanou, Herman Autrup, Nikolaos A. Demopoulos, Klea Katsouyanni, Radim Sram, and Soterios A. Kyrtopoulos (2005)
    Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations Carcinogenesis, Vol. 26, p.p. 93-101.
  60. Efi Pasmatzi, Dimitrios Vlastos, Alexandra Monastirli, Georgia Stephanou, Sophia Georgiou, Theophilos Sakkis, Dionysios Tsambaos (2005)
    Ehlers-Danlos Type IV Syndrome In A Patient With Down Syndrome : Simple Co–Occurrence Or True Association ?
    The Amrerican Journal Of The Medical Sciences, 331(10, P.P. 48-50.
  61. Constantinos Andrianopoulos, Georgia Stephanou, and Nikos A. Demopoulos (2006)
    Genotoxicity of hydrochlorothiazide in cultured human lymphocytes; I. Evaluation of chromosome delay and chromosome breakage Environmental and Molecular Mutagenesis, Vol. 47, p.p. 169-178.
  62. Georgia Stephanou, Michael Tyrakis, Asimina Kouloumenta, Constantinos Andrianopoulos.Nikos A. Demopoulos (2006)
    Increased Genomic Instability in Peripheral Lymphocytes of Down Syndrome Patients due to Increased Rate of Chromosome Non-Disjunction Abstracts of 36th Annual Meeting of the EEMS, p. 161, Prague, Czech Republic.
  63. M. Efthimiou, C. Andrianopoulos, G. Stephanou, N. A. Demopoulos, S. S. Nikolaropoulos (2007)
    Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-n,n-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 6177, p.p. 125-137.
  64. Ouranou D., Stephanou G., Demopoulos N.A. (2007)
    Frequencies Of Polymorphic Genes That Participate In: A) Dna Repair Mechanisms And B) Detoxification Mechanisms Of Chemical Compounds Through The Glutathione System In A Greek Population Sample. Proceedings of the 29th Annual Conference of the Hellenic Society for Biological Sciences, Kavala. Hellas, p.p. 309.
  65. R. Alakhras , M. Efthimiou , G. Stephanou, N.A. Demopoulos, S.S. Nikolaropoulos (2008) Human Lymphocytes Exposed In Vitro To All-Trans Retinoic Acid (Atra) And Its Steroidal Analogue (Ea-4) Exert Increased Micronucleus Frequency Proceedings of the 30th Annual Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Hellas, p.p. 19.
  66. M. Efthimiou, G. Stephanou, N.A. Demopoulos , S.S. Nikolaropoulos (2008)
    Comparative Study Of Genetic Activity Of Nitrogen Mustard Analogues Proceedings of the 30th Annual Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Hellas, p.p. 123.
  67. K. Trochoutsou , M. Efthimiou, G. Stephanou, N.A. Demopoulos (2008)
    Study Of The Relationship Between Apoptosis And Micronucleated Cells Induced By The Anticancer Drug Doxorubicin On The Mouse Cell Line C2c12 Proceedings of the 30th Annual Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Hellas, p.p. 485.
  68. Panayides A., Ouranou D., Stephanou G., Demopoulos N.A. (2008)
    Evaluation Of The Effect Of Polymorphism Ser326cys Of The Hogg1 Gene On The Cytogenetic And Cytotoxic Activity Of The Anticancer Drug Doxorubicin In Human Lymphocytes Cultured In Vitro Proceedings of the 30th Annual Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Hellas, p.p. 123.

III. CONFERENCES

  1. 1st Annual Conference of the Hellenic Society for Biological Sciences, Athens, Hellas, 19799
  2. 9th annual meeting of EEMS,Tucepi-Makarska, Yugoslavia, 1979
  3. 10th annual meeting of EEMS, Athens, Greece, 1980
  4. 3rd Annual Conference of the Hellenic Society for Biological Sciences, Athens, Hellas, 1981
  5. 4rh Annual Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Hellas, 1982
  6. 5th Annual Conference of the Hellenic Society for Biological Sciences, Patras, Hellas, 1983
  7. Abstracts of Special FEBS meeting on Cell function and differentiation, Athens, 1982
  8. International Conference in Biochemical and Developmental Genetics, Kos, Greece, 1983.
  9. 17th annual meeting of EEMS, Zurich, Switzerland, 1987
  10. 19th annual meeting of EEMS, Rhodes, Greece, 1989
  11. CEC Contact Group Meeting Report, Espoο, Finland, 1992
  12. 22nd annual meeting of EEMS, Berlin, Germany, 1992
  13. 23rd annual meeting of EEMS, Barcelona, Spain, 1993
  14. 24th annual meeting of EEMS, Poznan, Poland, 1994
  15. 17th Annual Conference of the Hellenic Society for Biological Sciences, Patras, Hellas, 1995
  16. 21st Annual Conference of the Hellenic Society for Biological Sciences, Syros, Hellas, 1999
  17. 1st European Conference on pesticides and related organic micropollutants in the environment, Ioannina, Greece, 2000
  18. 23rd Annual Conference of the Hellenic Society for Biological Sciences, Chios, Hellas, 2001
  19. 25th Annual Conference of the Hellenic Society for Biological Sciences, Mytilini, Hellas, 2003
  20. 1st Bioscience Conference of the University of Patras, Patras, Hellas, 2005
  21. 6th Conference of Medicinal Chemistry: Drug Discovery and Design. Patras, Hellas, 2005
  22. 35th Annual Meeting of the EEMS, Kos, Greece, 2005
  23. 36th Annual Meeting of the EEMS, Prague, Czech Republic,2006
  24. 29th Annual Conference of the Hellenic Society for Biological Sciences, Kavala. Hellas,2007
  25. 30th Annual Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Hellas, 2008

IV. PARTICIPATION IN EUROPEAN PROJECTS

  1. Biomonitoring of Human Populations Exposed to Genotoxic Chemicals
    1/1/1989‑31/12/1990. Contract No. EV4V‑0178‑GR(SP).
  2. Assessment of Environmental and Occupational Exposures to butadiene as a model for risk estimation of Petrochemical emissions.
    1/11/1991- 31/10/1993.
    Contract No. STEP-CT91-0152
  3. Multi-endpoint analysis of genetic damage induced by 1,3 butadiene and its major metabolites in somatic and germ cells of mice, rats and man, genetic risk estimation of the parallelogram method.
    1/11/1994-31/10/1995.
    Contract No. EV5V-CT94-0543
  4. Biomarkers of Genotoxicity of Urban Air Pollution: A Dose-Response Study. 1/6/1996 - 31/12/1998.
    Contract No. ENV4-CT96-0203

V. FUTURE RESEARCH PLANS
In the near future we will investigate the genotoxic and mainly the aneuploidogenic properties of anticancer drugs, which are currently used in cancer therapy, such as antibiotics, retinoids and nitrogen mustard analogues. In addition we will compare their activity to new compounds, synthesized as analogues of the above pharmaceutical categories and hopefully designed to exert enhanced anticancer activity and reduced toxicity.

UNIVERSITY OF PATRAS Department of Biology Patras, GREECE
The Department of Biology of the University of Patras was established in the year 1967 and was the first Biology Department in Greek University System. The Department is housed in a new 4 storey modern building, covering an area of 25.000 m2. It has excellent research facilities and ample office and classroom space. It also has a library a computing centre and a lecture room. The Department has over 50 faculty members who are active researchers and their work is published in international scientific journals. Representative areas of their research include: Cell and Molecular biology, Development, Genetics, Biochemistry, Microbiology, Biotechnology, Human Animal and Plant Physiology, Neuroscience, Marine Biology, Animal and Plant Ecology, Plant Morphology, Phytogeography, Plant Phylogeny, Systematic Botany, Zoology and Philosophy of life. The Department offers an undergraduate programme leading to specialization in the areas of Functional Biology and Ecology-Environmental Biology. It also offers a postgraduate programme covering the areas of Biological Technology and Ecology, Management and Protection of Natural Environment.

Chapter Highlights

  • Australian Chapter:- Dr Pam McGrath and her team, International Program of Psycho-Social Health Research (IPP-SHR), have worked closely with IRPC on a range of research projects.
  • Australian Chapter:- Hamish Holewa, IPP-SHR has contributed to the development of IRPC's journal, the Austral-Asian Journal of Cancer, a HERDC recognised, peer-reviewed, multi-disciplinary cancer journal.
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  • New Room provides an interactive forum for all the scientists and researchers to convey important information and news.
  • IRPC Japan Chapter under the leadership of Prof. Takashi Nakano in collaboration with NPO Japanese Organization for International Cooperation in Radiation Medicine has decided to donate Radiotherapy Machines to developing countries. The NPO has already donated a machine to Yemen.
    Brachytherpay machine project Yemen 11-25 January 2011.
  • IRPC is launching the new website with renewed contents and chapter details. The website will be continuously be updated with contributions from all chapters and associations.
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